摘要
通过兔腹主动脉阻断造成典型的脊髓二次损伤模型,用氢清除法连续监测脊髓血流量(SCBF)变化。缺血40分钟,SCBF下降60.75％,动物双后肢瘫痪。再灌流后SCBF逐渐恢复,再灌流4～6小时恢复并超过正常水平,此时,近一半动物双后肢运动功能完全或部分恢复;再灌流24小时SCBF再次下降54.89％,脊髓病理改变更为严重,动物双后肢再次瘫痪或加重。SCBF的变化与组织病理变化及动物双后肢运动功能有密切关系。结果提示:脊髓循环障碍在动物二次瘫痪过程中起着重要作用。
Changes of spinal cord blood flow(SCBF)were studied in rabbit model by occlusion abdominalaorta. At 40 min after occlusion SCBF decreased60. 75%, while the both hindlimbs were paralyzed.Then reperfusion lasted 1-3 hours SCBF recoveredgradually and at 4 hours after reperfusion SCBFwas beyond normal. Almost half of animalsregained near-normal motor function by 4 hoursafter complete paralysis during spinal cordischemia. At 24 hours of reperfusion SCBFredecreased 54. 89%. while light microscopyshowed that the number of necrotic neurons wasincreased, and the hindlimb function wasdeteriorating. The changes of SCBF correlatedwith hindlimb function. These results suggest thatobstruction of spinal cord microcirculation mayplay a main role in the secondary deterioration ofmotor function.
出处
《中华神经外科杂志》
CSCD
北大核心
1992年第2期111-113,共3页
Chinese Journal of Neurosurgery
