摘要
对转mtlD/ gutD 双价基因稻米进行了大鼠急性、亚急性毒性实验 ,致突变试验和 30d喂养试验。结果表明 ,大鼠经口LD50 >30g/kg体质量 ,无致突变作用 ;30d喂养试验中 ,18、36、5 4g/kg体质量各剂量组大鼠发育、增重、食物利用率、血常规、脏体比及病理组织学观察等各项指标与基础对照组相比均无显著差异。初步表明转mtlD/ gutD 双价基因稻米对大鼠来说是安全的。
Toxicity experiments, mutation experiments and 30-day feeding tests were conducted on rats with transgenic rice bearing mtlD/gutD gene. Results showed that oral LD 50 for rats was larger than 30 g/kg and no mutations were found. The rats groups with 18,36,54 g/kg-dosage had good development in 30-day feeding test. No obvious differences were found in the index of weight, food utilization rate, routine blood test, rate of organ to body (weight to weight), and patho-histological observations between the rats fed with or without the transgenic rice grain. It could be concluded that transgenic rice with mtlD/gutD gene was safe to the rats.
出处
《中国水稻科学》
CAS
CSCD
北大核心
2004年第3期208-212,共5页
Chinese Journal of Rice Science
基金
国家863计划资助项目(JY031310)
国家自然科学基金资助项目(30370132)
浙江省自然科学基金资助项目(302061)
中国水稻科学发展基金资助项目(0003239)
浙江省科技计划项目(011102186)
关键词
转基因食品
稻米
毒性试验
致突变试验
喂养试验
大鼠
transgenic rice
rice grain
toxicity experiment
mutation experiment
feeding test
