摘要
氧化代谢的增强是引起家蝇对二氯苯醚菊酯产生抗性的因素之一。抗性家蝇多功能氧化酶的萘羟化活性、对二氯苯醚菊酯的氧化代谢能力和微粒体细胞色素P_(450)含量分别是正常家蝇的2、1.48、1.33倍。正常家蝇和抗性家蝇细胞色素P_(450)在对增效磷(SV_1)和氧化胡椒基丁醚(Pb)的敏感性上也存在着差异。SV_1与多功能氧化酶专一性抑制剂Pb一样,对该酶系催化的萘羟化活性及二氯苯醚菊酯的氧化代谢有明显的抑制作用,这种抑制作用是SV_1在家蝇体内对二氯苯醚菊酯增效的机理之一。SV_1对氧化代谢的抑制与它和微粒体细胞色素P_(450)相互作用形成非活性复合体有关。
The increasing oxidative metabolism is one of the most important factors in house fly resistance to permethrin. The activity of mixed function oxidases (MFO) to naphthalene and permethrin and the cytochrome P450 content in the resistant flies were found to be 2-, 1.48-, 1.33-fold those in the susceptible ones respectively. The sensitivity of cytochrome P450 to SV1 and Pb was also different 'between the two strains.SV1 had strong inhibitory effect to MFO activity of naphthalene hydroxylation and permethrin oxidative: metabolism. This is one of the SV1 synergism mechanisms to permethrin. The SV1 inhibition to oxidative metabolism is concerned with its effect on microspmal, cytochrome P45o to form inactive complex.
出处
《昆虫学报》
CAS
CSCD
北大核心
1989年第1期26-31,共6页
Acta Entomologica Sinica
关键词
家蝇
二氯苯醚菊酯
氧化代谢
housefly--permethrin resistance--MFO--cytochrome P450---SV2.inliibition
