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p53基因突变在胃癌发生中的作用 被引量：2

The function of p53 mutation during the process of gastric cancer
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摘要 胃癌的发生发展是多基因参与、多步骤进行的过程。而p5 3基因突变作为一种重要抑癌基因失活方式 ,在其中发挥了重要作用。现综述近年来在胃癌中发现的p5 3基因突变类型、方式。
作者 许晶虹 陈丽荣
机构地区 浙江大学医学院附属第二医院病理科
出处 《国外医学（肿瘤学分册）》 2004年第4期283-286,共4页 Foreign Medical Sciences (Cancer Section)
关键词 P53基因 基因突变 胃癌 肿瘤生物学 抑癌基因
分类号 R735.2 [医药卫生—肿瘤]
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参考文献23

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  • 2Shiao YH, Palli D, Buzard GS, et al. Implications of p53 mutation spectrum for cancer etiology in gastric cancers of various histologic types from a high-risk area of central Italy. Carcinogenesis, 1998,19(12) :2145-2149.
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同被引文献11

  • 1杨志宏,王智彪.细胞凋亡信号转导与肿瘤细胞凋亡抵抗机制[J].国外医学（肿瘤学分册）,2004,31(8):579-582. 被引量：7
  • 2张娜.肿瘤抑制基因P^(53)研究进展[J].中国中西医结合外科杂志,2004,10(4):337-339. 被引量：2
  • 3Wu CF, Bishopric NH, Pratt RE. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes[J]. J Biol Chem,1997,272:14 860-14 866.
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  • 6Catherine C,Krishna S, David RP,et al. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-Adrenergic pathway[J]. Circulation,1998,98:1 329-1 334.
  • 7Yashiro M,Carethers JM,Laghi L,et al.Genetic pathways in the evolution of morphologically distinct colorectal neoplasms[J].Cancer Res,2001,61:2676-2683.
  • 8Fishel R,Lescoe MK,Rao MRS,et al.The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer[J].Cell,1993,75:1027-1036.
  • 9Leach FS,Nicolaids NC,Ppadopalos N,et al.Mutation of a muts homolog in hereditary nonpolyposis colorectal cancer[J].Cell,1993,75:1215-1221.
  • 10李佩玲,刘梅梅,倪江.错配修复基因hMSH2研究的新进展[J].国外医学（遗传学分册）,2002,25(4):224-227. 被引量：10

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国外医学（肿瘤学分册）
2004年 第4期

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