摘要
目的 :探讨血浆亚硝酸根 (NO2 -)及环磷酸鸟苷 (cGMP)浓度诊断早产的临床意义。方法 :采用示波极谱法和放射免疫法测定 32 2例妊娠妇女 (2 4 0例正常妊娠妇女、30例正常产妇和 5 2例早产妇女 )血浆NO2 -和cGMP浓度。结果 :正常妊娠妇女从 2 8周开始 ,血浆NO2 -和cGMP浓度均逐渐增加 ,在足月及产后又分别下降。血浆NO2 -和cGMP浓度分别在 34～ 34+ 6周和 33～ 33+ 6周达最高值。足月妊娠时血浆NO2 -浓度与妊娠 33～ 33+ 6周、34～ 34+ 6周、36～ 36 + 6周比较 ,明显降低 ,差异均有显著性 (P <0 0 5 )。足月妊娠血浆cGMP浓度与妊娠 33～ 33+ 6周、35～ 35 + 6周、36～ 36 + 6周比较 ,亦明显降低 ,差异有显著性 (P均 <0 0 0 5 )。早产妇女血浆NO2 -和cGMP浓度均低于相应孕周的正常妊娠妇女 (P <0 0 0 1,P <0 0 5 )。血浆NO2 -和cGMP浓度诊断早产的敏感性和特异性分别为 86 36 %、80 %和 82 12 %、78 5 6 %。结论 :血浆NO2 -和cGMP浓度在诊断早产上可能具有良好的临床应用前景 。
Objective: To investigate the clinical significance of serum NO 2- and cyclic guanosine monophosphate (cGMP) levels to diagnose preterm delivery. Methods: 322 pregnant women were enrolled, including 240 normal pregnancies、30 normal full-terrn delivery women, and 52 preterm pregnancies. The serum NO 2- and cGMP levels were examined by oscillopolarography and radioimmunoassay. Results: The serum NO 2- and cGMP levels gradually increased from 28 to 36 +6gestational weeks in normal pregnancy, then they gradually decreased in the term and post-partum. The highest serum NO 2- and cGMP levels were observed in 34～34 +6 and 33～33 +6 gestational weeks, respectively. The serum NO 2- and cGMP levels in full-term pregnancies were significantly lower than fhose in 33～33 +6,35～35 +6,and 36～36 +6 gestational weeks (P<0.05 and P<0.005,respectively). The serum NO 2- and cGMP levels in preterm pregnancy were significant decreased when compared to those in the normal pregnancy (P<0.001, P<0.05). The sensitivity and specificity of serum NO 2- and cGMP levels to diagnose preterm delivery were 86.36%、80% and 82.12%、78.56% respectively. Conclusions: These data suggesed that it may be useful to detect the serum NO 2- and cGMP levels to diagnose preterm delivery. More experiments should be carried out in the following study.[
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2004年第2期102-103,共2页
Journal of Practical Obstetrics and Gynecology
基金
四川省卫生厅基金资助 (编号 :0 0 0 0 4 0 )
