摘要
本研究利用ＳＤ大鼠心肌缺血－再灌注模型，通过用左型精氨酸及左型精氨酸甲酯的干预，探讨一氧化氮对ＳＤ大鼠血压和心率的影响。实验分缺血－再灌注模型组、左型精氨酸干预组及左型精氨酸甲酯干预组。结果显示：左型精氨酸和左型精氨酸甲酯均减慢ＳＤ大鼠的心率；左型精氨酸具有降低血压作用，左型精氨酸甲酯具有升血压及抗低血压的作用。本文结果为临床应用一氧化氮制剂提供了实验依据。
The effects of L Argine(L Arg) and L N G Argine Methyl Ester(L NAME) on blood pressure and heart rate in myocardiac ischemic reperfusion(I/R) rats were studied. 75 rats were divided into three groups: myocardiac I/R group, L Arg infusion group and L NAME infusion group. The results showed that compared with the myocardiac I/R group, the heart rate decreased both in L Arg infusion group and in L NAME infustion group, and that the blood pressure was lower in L Arg infusion group but higher in L NAME infusion group. It is suggested that both L Arg and L NAME slow the heart rate, and that L Arg may produce hypotension, however, L NAME may be helpful to anti hypotension.
关键词
再灌注损伤
精氨酸
精氨酸甲酯
心率
血压
reperfusion injury L argine L NAME heart rate blood pressure hemodynamics nitric oxide rats
