摘要
为了研究参茜固经冲剂作用机理,本文收集参茜固经冲剂治疗的原发性月经过多患者37例,按中医辨证分血瘀为主和气虚为主两组,测定其治疗前后月经失血量、子宫内膜和月经血前列腺素PGE_2,PGF_(2α),6-Keto-PGF_(1α)及TXB_2含量。结果总有效率84.8%,月经血量平均减少30.7%;患者子宫内膜及月经血TXB-2均高于正常妇女,但不同中医分型PGE_2表现不同,以血瘀为主者PGE_2低于正常,气虚为主者PGE_2高于正常。治疗后血瘀组TXB_2降低,PGE_2升高,气虚组PGE_2及TXB_2均降低,呈双相反应。结果提示,本制剂对子宫局部前列腺素有双相调节作用,药物的治疗作用可能与子宫局部前列腺素的平衡恢复有关。
Shen Qian Gujing Granule, a Chinese herbal preparation has shown its efficacy of 87.7% in treating monorrhagia. PGE_2, PGE_2α, TXB_2, and 6-Keto-PGF_1α Ievels were measured in the endo- metrium and menstrual blood of both normal menstrual women and patient with menorrhagia beforeand after the treatment. Local TXB_2 values of endometrial and menstrual blood were significantlyhigher in menorrhagia patients than that in normal subjects(P<0.05). And the local PGE_2, valueswere higher in patients accompanied with Qi Deficiency (P<0.05) and lower in patients without QiDeficiency (P<0.05). After the treatment, the local TXB_2, PGE_2 levels normalized. It suggests thatShen Qian Gujing Granule had a biphasic regulation on local PG values which yields good results formenorrhagia. Some mechanism were discussed.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第12期730-733,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
月经过多
参茜固经冲剂
血栓素B2
menorrhagia
Shen Qian Gujing Granule
postaglandin
PGE_2
PGF_(2α)
6-keto-PGF_(1α) TXB_2
