摘要
用兔出血热病毒（ＲＨＦＶ）造成家兔病毒性发热模型，观察抗戾散的退热作用。结果表明：家兔腹腔注射１：５０的ＲＨＦＶ１ｍｌ后２０～２４ｈ开始发热，直肠温度升高１．５℃～２．５℃，发热持续５～７ｈ。腹腔注射２００％抗戾散（４ｇ／ｋｇ体重）可以有效地抑制实验家兔的发热效应，并能降低其脑脊液前列腺素Ｅ２和环核苷酸等发热介质，与模型组比较差异显著（Ｐ＜０．０１）。提示抗戾散不仅有抗病毒作用，而且还能通过多种途径作用在体温调节中枢发生退热降温效应。
The hypothermic effect of Kangli San(KLS) on the model of rabbit viral hyperpyrexia caused by rabbit hemorrhagic fever virus was studied.Intraperitoneal injection of 200% KLS(4g/kg) could inhibit the pyrogenic action of the virus efficiently.The results showed that KLS could decrease the function of pyrogenic transmitters such as PGE2 and cAMP etc.in cerebrospinal fluid.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第9期543-545,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
病毒性
发热
环核苷酸
抗戾散
Kangli San,viral hyperpyrexia,prostaglandin E_2,cyclo-nucleotide
