摘要
睾丸酮可以促进受损舌下及面神经的再生和延长神经细胞的存活。但对两者作用的时限不同。在轴突切断后的前四周内给予睾丸酮可以促进神经再生,而在后五周内则可以减少神经细胞的死亡。为证实睾丸酮第一作用部位在效应肌而非神经元的设想,应用雄激素受体的阻断剂HF,检查其对睾丸酮神经营养性作用的影响。结果证明,HF可以完全消除睾丸酮对切断轴突的运动神经元所具有的促进存活作用。
In order to further explore the hypothesis that muscles are the primary action site for testosterone, the present study examined the effect of androgen receptor blockade in effector muscles on the efficacy of testosterone in preventing neuronal cell loss following axotony. Hydroxyflutamide (HF), an androgen antagonist that acts competitively at the honnone receptor site, was administered into muscles of the tongue when animals were treated with testosterone following unilateral transection of the hypoglossal and facial nerves. The ability of testosterone to prevent neuronal cell loss in the axotomized hypoglossal and facial motor nucleus was exanined. The results demonstrated that hydroxyflutamide completely negates the survival-promoting effect of testosterone on axotomized motoneurons.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1992年第4期280-283,共4页
Acta Academiae Medicinae Sinicae
关键词
舌下神经核
面神经运动核
睾丸酮
testosterone hypoglossal nucleus facial motor nucleus hydroxyflutamide
