摘要
用抗-HCV EIA法检测献血员和非甲非乙型肝炎病人的抗-HCV。ALT异常献血员抗-HCV阳性率(37.5%)明显高于ALT正常献血员(2.9%),抗-HCV与ALT异常密切相关,提示用ALT加上抗-HCV筛选献血员将大大减少输血后NANBH的危险性。HCV是输血后和慢性NANBH的主要原因,是散发性NANBH的重要原因。抗-HCV检出率随着病程的延长而升高,但抗-HCV出现时间较迟。
We measured antibody to hepatitis C virus (anti-HCV)by anti-HCV EIA in blood donors and patients with Non-A, Non-B hepatitis (NANBH). Prevalence of anti-HCV (37.5%) in donors who had raised ALT levels was higher than that in donors (2.9%) who had normal ALT levels. There was a strong correlation between anti-HCV positivity and raised ALT levels. This association suggests that donor screening for elevation of ALT level was at least partially effective in preventing transfusion-associated Non A, Non-B hepatitis (NANBH). The detection of anti-HCV in donors who had normal ALT levels suggests that donor screening for anti-HCV will further reduce the risk of transfusion associated NANBH. Among patients with NANBH anti-HCV antibodies were found in 87.9% of patients with post-transfusion NANBH, 46.4% of patients. with sporadic NANBH and 86.4% of patients with chronic NANBH. The positive rates of anti-HCV increased with prolongation of course of the disease, but the develepment of anti-HCV was delayed.
出处
《中国医科大学学报》
CAS
CSCD
1992年第4期281-284,共4页
Journal of China Medical University
关键词
献血员
丙肝病毒
丙型肝炎
blood donor
ALT
non-A, non-B heratitis
viral hepatitis type C
antibody to hepatitis C virus
