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肺炎患者血清一氧化氮含量测定的临床意义

The clinical significance of nitric oxide concentration of plasma in patients wi th pneumonia
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摘要 目的 探讨肺炎患者治疗前后血清一氧化氮 (NO)改变的临床测定意义。 方法 采用分光光度法对 4 2例肺炎急性期和恢复期患者进行了血清NO含量检测并与正常健康者进行了对比。 结果 治疗前肺炎组NO水平 7 6 5 9μmol L± 1 76 2 μmol L较对照组 2 6 5 3μmol L± 0 315 μmol L显著增高 (P <0 0 5 ) ;治疗后NO水平4 0 18μmol L± 1 10 7μmol L与对照组比较无显著差异 ;肺炎组治疗前后比较NO水平明显下降 (P <0 0 5 )。 结论 NO可能参与肺炎的发生和发展过程。 Objective To investigate the clinical s ignificance of nitric oxider(NO) concentration of plasma in patients with pneumo n ia. Methods Plasma NO concentration of 42 patients were measu red by spectrophotometry respectively in acute and convalescence period and compared with nornal control. Results Before treatment plasma NO concentration(7.659μmol/ L±1.762μmol/L) was higher obviously in pneumonia group than that in normal group(2.653μmol/ L±0.315μmol/L) ( P <0.05),but there was no difference after treatment(4.018μmol/L±1.107 μmol/L).Plasma NO concentration of pnemonia group declined significantly after treatment. Conclusion NO might take part in the development of pneumonia .
出处 《实用心脑肺血管病杂志》 2004年第2期81-82,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 肺炎 血清 一氧化氮 含量 测定 Ntric oxide Pneumonia
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参考文献3

  • 1[1]Monccada S,Palmer RMJ,Higgs EA.Nitric oxide:physiology,pathophysiology and pharmacology[J].Pharmacol Rev.1991,43:109.
  • 2[2]Yaghi A,Mccormack DG.Pulmonary artery ccontractility in pneumonia:role of cyclooxygenase products and nitric oxide[J].J Cardiovas Pharmacol.1999,34:468~474.
  • 3[3]Barnes PJ,Belvisi MG.Nitric oxide and lung disease[J].Thorax.1993,48:1034.

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