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阿片受体激动药伍用小剂量拮抗药用于镇痛的研究进展 被引量:33

Effect of Combining Opioid Agonists and Low Doses of Opioid Antagonists for Pain Management and Control
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摘要 阿片受体具有双向作用模式;阿片受体激动药与Gs蛋白耦联的阿片受体结合,产生兴奋性作用即痛超敏,与Gi/Go蛋白耦联的阿片受体结合会产生相反的作用,即镇痛效应;伍用(超)小剂量阿片受体拮抗药不拮抗甚至增强激动药的镇痛效能,同时有效减少副作用;对这方面的基础和临床研究进展及其机制探讨进行综述。
出处 《国外医学(麻醉学与复苏分册)》 2004年第2期80-83,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
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  • 1曹君利,曾因明,张励才,顾均,周文华,杨国栋.NO参与介导吗啡戒断大鼠脊髓神经元敏感化[J].生理学报,2001,53(1):75-78. 被引量:10
  • 2Shen KF, Crain SM. Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence. Brain Res,2001,919(1) :20-30.
  • 3Yang W, Law PY, Guo X, et al. In vivo activation of a mutant mu-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proc Natl Acad Sci USA, 2003, 100(4): 2117-2121.
  • 4Mehlisch DR. The combination of low dose of naloxone and morphine in patient-controlled (PCA) does not decrease opioid requirements in the postoperative period. Pain, 2003,101 (1-2) :209-211.
  • 5Sartain JB, Barry JJ, Richardson CA, et al. Effect of combining naloxone and morphine for intravenous patient-controlled analgesia. Anesthesiology,2003,99( 1 ): 148-151.
  • 6Gear RW, Cordon NC, Miaskowski C, et al. Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans.Neurosci Lett, 2003,351 (1):5-8.
  • 7Ammer H, Christ TE. Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity.J Neurochem,2002,83(4) :818-827.
  • 8Ono T, Inoue M, Rashid MH, et al. Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism. Nenrochem Int,2002,41 (6) :399-407.
  • 9Lee J, Shim JY, Choi JH, et al. Epidural naloxone reduces intestinal hypomotility but not analgesia of epidural morphine. Can J Anaesth,2001,48(1) :54-58.
  • 10Choi JH, Lee J, Choi JH, et al. Epidural naloxone reduces pruritus and nausea without affecting analgesia by epidural morphine in bupivacaine.Can J Anaesth,2000,47(1) :33-37.

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