摘要
流行病学调查证明,长期食用鱼类的格陵兰爱斯基摩人心血管发病率较低,与鱼油含有n-3系多不饱和脂肪酸即二十碳五烯酸(eicosapentaenoic acid,EPA),二十二碳六烯酸(docosahexaenoic acid,DHA)有关.据报道,鱼油具有调整血脂,抑制血小板聚集,延缓血栓形成等作用.本实验研究鱼油主要成分EPA对前列环素I_2(prostacycline I_2,PGI_2)
In the biological assay, the rat arterial wall was incubated in a solution of Tris+EPA (0.5 mmol·L-1) and the rat platelet aggregation induced by ADP (5 μg·ml-1 PRP) could be inhibited by the solution. The inhibition rate was 63± s 19%, and that of the control (Tris+Na2CO3) was 29± s 11 %. The production of the PGI2-like substance could besignificantly raised by EPA (P<0.01,n = 6).The radioimmunoassay showed that EPA reduced the level of TXB2 and increased significantly 6-keto-PGFlαTXB2 ratio in the mouse plasma after the administration of EPA (10 mmol·L-1 EPA, 5μl·g-1, 5d,ip).
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1992年第3期237-238,共2页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金 № 3880740
关键词
二十碳五烯酸
前列环素
血栓素
eicosapentaenoic acid platelet aggregation 6-keto-PGF1αthromboxane B2 prostacycline I2 thromboxane A2
