摘要
在犬右心房表面脂肪组织中发现31±s13个神经节或1983±s331个神经元(n=6).在30只麻醉开胸犬的右心房神经节丛内注射尼古丁100μg,引起心脏各部分的正性或负性的变时性和变力性变化;注射生理盐水于右心房神经节丛或注射尼古丁(100μg和200μg)于右缘区神经节丛均未引起心功能变化,急性心脏去神经支配后,重复注射尼古丁在右心房神经节丛的同样部位仍然引起心脏的正性或负性反应.但反应率减少.研究表明,尼古丁可兴奋犬右心房神经节丛,内节后副交感神经元。节后交感神经元和传入神经元。这些对尼古丁敏感的神经元以不同张力调节着心脏各部分的功能。
It was found that there were 31±s 13 ganglia or 1983 ±s 331 neurons ( n = 6) in canine right atrial ganglionated plexus (RAGP). Nicotine (100 μg) was administered to the plexus in 30 anesthetized open-chest dogs. Either positive or negative inotropic and chronotropic responses were elicited. Control injections of 0. 1 m1 NS into RAGP and injections of nicotine (100 μg and 200μg) did not elicite any cardiac responses. Following acute decentralzation of hearts, nicotine (100 μg ) was again
administered to RAGP. Some positive and negative responses were still elicited, but frequency of the responses was reduced. It is concluded that nicotine can directly activate efferent sympathetic and parasympathetic neurons of RAGP. and indirectly activate them by stimulation of afferent neurons, these nicotine sensitive cardiac neurons can modulate cardiac function in ifferent tendencies.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第5期357-361,共5页
Chinese Pharmacological Bulletin
关键词
心脏
神经节
烟碱
nicotine
cardiac
ganglion
efferent
afferent
