摘要
显微解剖发现犬主动脉和肺动脉间神经节丛(A-PGP)有大量神经节或神经元,注射烟碱100μg于30只犬的A-PGP,在完整心脏和去神经支配心脏均引出正性或负性变时性和变力性反应,心脏急性去神经支配后,反应频数降低。结论:烟碱可直接兴奋心脏表面节后交感神经元和副交感神经元,也可靠刺激传入神经元间接兴奋它们。
In order to study the location and function of nicotine-sensitive neurons of cardiac ganglial plexuses, microdissections of collections of fat pads were carried out, and nicotine (100 μg) was injected into the ganglial plexus between aorta and pulmonary artery (A-PGP) in 30 anesthetized open-chest dogs. There were numerous ganglia or neurons in A-PGP. Either positive or negative inotropic and chronotropic responses were elicited following injections of nicotine into A-PGP. Control injections of 0. 1 ml saline into A-PGP and injections of nicotine (100 or 200 μg) into right marginal ganglial plexus did not elicit any cardiac responses. After acute decentralization, nicotine (100 μg) was again injected into the same locus of A-PGP. Some positive and negative responses could still be induced, but their frequencies were reduced. These suggest that nicotine can directly activate the efferent parasympathetic and sympathetic neurons and indirectly activate them by stimulating the afferent neurons existing on the surface of dog heart.
出处
《中国药理学报》
CSCD
1994年第4期331-335,共5页
Acta Pharmacologica Sinica
关键词
烟碱
心脏
交感神经节
神经元
nicotine
heart
parasympa- thetic ganglia
sympathetic ganglia
neurons
efferent pathways
afferent pathways
