摘要
从雷公藤多甙中分离出的单体T_9(雷醇内酯)有明显抗精子发生作用。T_9喂服雄鼠剂量为0.1mg/kg·d^(-1),喂服7周后处死观察,睾丸组织结构损伤轻微,而附睾精子有明显损伤,表现为精子尾部中段鞘膜崩解,特别是精子头尾大量分离,其分离率高达90%以上;但T_9并不引起精子头部明显畸变,没有明显免疫抑制作用,对主要脏器没有损伤,其抗生育效果是雷公藤多甙的100倍。
A ready-made Chinese herb containing the glycosides of Tripteri-gium wilfordii ( GTW ) have been reported to cause testicular atrophy in men. Various fractions isolated from GTW were screened in experiments on rats and mice to observe their antifertility effects and found that the monomer T9 among the requirements for male contraceptive need to be elucidated. T9 was administered through gastric intubation at a dose of 0.1mg/kg·d-1 7w· All the T9 treated rats exhibited minimal testicular damage at the end of seventh week of treatment, but causes severe damages mainly the epididymal, the spermatozod showed various structural abnormalities, including cracked midpiece, decapitation of the sperm head commonly ( above 90% ) . It is no malformed round or tadpoleshapes head sperms discernible, no significant changes were seen in main visceral organs, no immunosuppressive actions was observed. The potencies of anti-sperm activity of T9 is 100 times stronger than GTW.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第2期115-118,共4页
Chinese Pharmacological Bulletin
基金
国家"七五"攻关内容
