摘要
雷公藤多甙(GTW)抗生育作用部位主要在睾丸内,可致圆形精子细胞向长形精子转变过程受阻,附睾中出现大量头部异常的精子,精子头尾分离和贮积大量不活动精子。从雷公藤多甙分离的有效抗生育单体T_4,抗生育剂量为GTW的1/200,主要作用于附睾精子,对睾丸形态结构及精子形态的影响不明显。提示T_4作用部位较理想。
The antispermatoggenic effects of the multiglycosides of Tripterygium wil- fordii (GTW) and monomer T4 isolated from GTW on the testes and epidid- ymal spermatozoa of rats were examined microscopically following silver stain ing. The dosages of GTW and T4 were 10mg/kg. d and 0. 05mg/kg·d, re- spectively, fed for 7 weeks via gastric intubation. Different degrees of damage to the testis and epididymal tubes were found in rats treated with GTW. Deformed, round--headed sperms and exfoliated cells (mainly spermatids and occasionally pachytene spermatocytes) were seen in the tubular lumen of the epididymis. Spermatids with deformed acrosomal vesicles were also commonly observed. No significant pathological changes were seen in other internal organs. T4 mainly caused damage to the spermatozoa in the epididymis. Under the dosage of 0.05mg/kg·d the sperm count was almost nil, but no discernible changes in the seminiferous tubules, epididymal epithelia, Leydig cells or Sertoli cells were found. The antifertility potency of T4 was 200 times stronger than that of GTW.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第4期235-240,共6页
Acta Academiae Medicinae Sinicae
基金
国家"七五"攻关课题
关键词
雷公藤多甙
抗生育作用
精子发生
glycosides of Tripterygium wilfordii male antifertility effect spermatogenesis
