摘要
WSALK和FSALK能抑制小鼠腹腔和皮肤毛细血管通透性,抑制二甲苯、角叉菜胶所致的炎性水肿,减少急性胸膜炎渗液量,抑制白细胞游走,对棉球肉芽增生也有一定抑制作用;对肾上腺、胸腺重量以及血浆皮质醇含量无明显影响;但可降低炎症组织中PGE含量。提示其抗炎作用与抑制PGE合成及释放有关。用小鼠二甲苯性耳水肿模型测得抗炎治疗指数:WSALK比FSALK大2.07倍。
The anti-inflammatory of waterand fat-soluble alkoloids of Leon-tice Kiagnanensis (WSALK, FSALK ) were described after sc of WSALK (150, 300 mg/kg ) and FSALK (13, 26mg/kg ) . The increased capillary permeability in abdominal cavity and skin of mice induced respectively by 0.7% HAc and histamin were inhibited abviously. WSALK (75, 150, 300mg/kg, ip ) and FSALK (6.5, 13, 26mg/Kg, ip ) markedly inhibited the ear inflammation induced by xylene in mice, carrageenin-iaduces swelling of the ankle in normal on adrenalecto-mized rats, and carrageenin-induced pleurisy in rats. Both compound also inhibited the granuloma induced by cotton pellet after sc of WSALK 300, 600 mg/kg and FSALK 13, 26 mg/kg qd × 7d.Both compound decreased the content of PGE in exudate formed after injecting carrageenin into the hind paw of rats. These results suggest that both compounds passesses the anti-inflammatory activity and their actions might be relatied to their inhibiting the synthesis or relase of pro-staglandin E. WSALK TI 9.35, FSALK TI 4.50.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第1期42-46,共5页
Chinese Pharmacological Bulletin
关键词
江南牡丹草
总碱
抗炎作用
Total alkaloid of Leontice Kiagnanensis
Anti-inflammatory effect
