摘要
以喹诺酮类药物作为质粒消除剂,进行抗生素耐药质粒定位实验。通过10株金黄色葡萄球菌耐药株的实验,确定其中3株菌具有氯霉素、四环素和红霉素耐药质粒。并比较了喹诺酮类与SDS的消除作用,发现在不同浓度的消除剂及不同菌株中其消除作用不相同。
Elimination of antibiotic-resistant plasmids in S. aureus by quinolones and SDS was reported. It was demonstrated that among ten tested strains of S. aureus, tetracycline, chloromycetin and erythromycin resistance plasmids were found in three strains 85094, 85040 and 90013. By comparing elimination rates for quinolone and SDS, it was revealed that the effect on plasmid elimination was variable under the condition of different concentrations of curing agents and different strains.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第4期243-247,共5页
Journal of China Pharmaceutical University
