摘要
目的:探讨青年脑梗死患者血浆纤溶活性和蛋白C系统变化及其临床意义。方法:临床收集25例青年脑梗死患者、29例对照者血液标本,采用产色法测定血浆纤溶酶原、(plasminogenactivator,PA)、(plasminogenactivatorinhibitor-1,PAI-1)活性,比浊法测定蛋白C和蛋白S活性,同时常规测定血脂水平。结果:①青年脑梗死组(1.10±0.43)IU和皮质支脑梗死组(0.99±0.48)IU血浆PA活性较对照组(1.46±0.50)IU显著降低(分别t=2.777,P=0.008;t=2.932,P=0.006)。皮质支脑梗死组PAI-1活性(2.30±0.59)IU较腔隙性梗死组(2.97±0.93)IU低(t=2.074,P=0.049)。②青年脑梗死组血浆蛋白S和蛋白C水平与对照组相比,无明显差异。③多元统计分析结果显示:PA和高血压对青年脑梗死的发生有显著作用。结论:PA和高血压分别是青年脑梗死患者的独立危险因素。
AIM:To investigate the changes of plasma fibrinolysis and protein C systems in young patients with cerebral infarction and their clinical significance. METHODS:Blood samples were collected from 25 young patients with cerebral infarction and 29 controls. Activities of plasminogen, plasminogen activator(PA) and plasminogen activator inhibitor 1(PAI 1) were determined by chromogenic substrate assay,and protein C activities were measured by turbidimetry. RESULTS:PA activity in the young patients with cerebral infarction[(1.10±0.43)IU]and with cortical infarction[(0.99±0.48)IU]both decreased significantly as compared with that in the controls[(1.46±0.50) IU](t=2.777,P=0.008;t=2.932,P=0.006 respectively ). PAI 1 activity in the patients with cortical infarction[(2.30±0.59) IU]was lower than that in the patients with lacunar infarction[(2.97±0.93) IU](t=2.074,P=0.049). There were no significant differences in the levels of protein C and protein S between the patients and controls.Multivariate statistical analysis indicated that PA and hypertension played a remarkable role in the occurrence of cerebral infarction in the young adult. CONCLUSION:Both PA activity and hypertension are important risk factors for cerebral infarction in the young adult.
出处
《中国临床康复》
CSCD
2004年第10期1888-1889,共2页
Chinese Journal of Clinical Rehabilitation
