摘要
采用药动学-药效学结合模型研究稳态乙胺碘呋酮对乙酰普鲁卡因胺(NAPA)的药动学和QT间期延长作用的影响,兔单独ⅳNAPA后,其β,K_(eo),S,EC_(50),E_(max)分别为0.0060±0.0006 min^(-1),0.061±0.017 min^(-1),2.19±0.39,6.21±1.74 μg/ml,53.6±2.5 ms;在稳态乙胺碘呋酮存在下ⅳNAPA后,分别为0.0086±0.0007 min^(-1),0.024±0.006 min^(-1),1.56±0.15,2.48±0.12 μg/ml,88.3±7.1 ms,结果表明乙胺碘呋酮可以增强并延长NAPA对QT间期的延长作用,并使NAPA的药物动力学和效应动力学的某些参数发生变化。
The pharmacokinetics and QT interval prolongation of N-acetylprocainamide (NAPA) were assessed alone and during concomitant adminstration of amiodarone by combined pharmacokinetic-pharmacedynamic model in rabbits. When the pharmacokinetic profiles and QT interval prolongation of NAPA were evaluated in the presence of steady state amiodarone, there were significant changes in pharmacokinetic and effect para meters. The values of β, K_∞, S, EC_(50), E_(max) were 0.0060±0.0006 min^(-1), 0.061±0.017 min^(-1), 2.19±0.39, 6.21±1.74 μg/ml, 53.6±2.5 ms respectively when NAPA was given alones. The valuse of β, K_∞, S, EC_(50), E_(max) were 0.0086±0.0007 min^(-1), 0.024±0.006 min^(-1), 1.56±0.15, 2.48±0.12 μg/ml, 88.3±7.1 ms respectively when NAPA was given in the presence of steady state amiodarone. Lengthening of the QT interval associated with NAPA was greatly increased in the presence of amiodarone.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第1期22-24,共3页
Journal of China Pharmaceutical University
关键词
普鲁卡因
药物动力学
胺碘酮
N-acetylprocainamide
Amiodarone
Pharmacokinetics
