摘要
采用８种动物实验性心律失常模型观察了普鲁托品（ｐｒｏｔｏｐｉｎｅ）的抗心律失常作用。结果表明，普导托品对由乌头碱、氯化钙、苯－肾上腺素引起的大鼠心律失常、氯仿所致的小鼠心室纤颤、电刺激所致的家兔心室纤颤均有保护作用。其作用机制似主要与其阻滞心肌细胞Ｎａ￣＋通道，延长有效不应期有关。
Protopine is an isoquinol ine alkaloid isolated from Dactglicapnos scandens Hutch. We studied its antiarrhythmic effects on experimental arrhythmia, It could elevate the dose ofaconitine to induce VP,VT and VF in rats and increase the dose of strophanthine K to induce VPin guinea pigs,It also shortened the duration of central arrhythmia induced by aconitine in ratsand the duration of arrhythmia induced by benzene-adrenaline in rats. It prevented rats and micefrom arrhythmia induced by iv CaCl_2 rapidly and inhalation of chloroform,respectively. In anaes-thetized rabbits,the drug raised the VFT after administration. In conclusion,protopine hasantiarrhythmic effects on various animal models and the study suggested that it may havedirective inhibitions on rapid electrical activity of the cardiac cells.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第2期81-84,共4页
Chinese Pharmaceutical Journal
