摘要
根据流体动力学平衡控释系统hydrodynamically balanced controlled drug delivery system,简称HBS^(TM))原理研制了复方潘生丁-HBS^(TM)系统。复方潘生丁-HBS^(TM)的体外溶出符合一级动力学过程,同位素γ-闪烁照相结果表明复方潘生丁-HBS^(TM)在胃内滞留时间(4～6 h)明显长于普通片(1～2 h)。采用荧光分光光度法测定了人单剂量口服复方潘生丁-HBS^(TM)及复方潘生丁市售普通胶囊(德国宝云家殷格翰大药厂)的潘生丁和水杨酸的血清浓度,并进行了药动学模型的拟合及药动学参数的估算,本品的体内外数据相关性显著(P<0.05)。
A persantin plus tablet remaining-floating in stomach was developed based on the hydrodynamically balanced drug delivery system (HBS^(TM)), which can prolong the residence time of drug in the GI tract and improve the bioavailability. The dissolution rate in vitro of Co-dipydamole was determined. The residence time in human's stomach was observed by using γ-scintiphoto technique. The conventional persantin plus capsules (Boehringer Ingelheim, Germany) were compared with Co-dipydamole-HBS^(TM) tablets in vivo. The serum levels of dipyridamole and salicylic acid were determined by fluorescence chromatography. The pharmacokinetic characteristics of dipyridamole and salicylic acid was studied. The fraction of dipyridamole and salicylic acid observed from Co-dipydamole-HBS^(TM) in vivo was correlated with the corresponding dissolution rate in vitro.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第1期14-18,共5页
Journal of China Pharmaceutical University
关键词
药物动力学
派醇啶
乙酰水杨酸
Dipyridamole
Aspirin
Pharmacokinetics
Antithrombotic
