摘要
研制了乙吗噻嗪胃内滞留漂浮型缓释片剂（Ｅ－ＨＢＳ）。实验结果表明：本品的体外溶出符合一级动力学过程（Ｋｒ＝０．２４３６ｈ－１）；人体胃内γ－闪烁照像显示ＥＨＢＳ在胃内滞留时间长达６ｈ以上，明显长于市售普通片（ＥＣＴ１～１．５ｈ）；血药浓度经时曲线平缓持久，达到良好的缓释效果；体内外实验数据有显著的相关性（Ｐ＜０．０１）。
An oral sustained-release system of cthmozm0(E-HBS)was developed.The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics(Kr=0.2436h-1).The γ-scintiphotographic study showed that E-HBS remained in the human stomach formore than 6 hours after ingestion,much longer than the conventional tablet(1～1.5h).The plasmaconcentration-time curve of E-HBS exhibited typical sustained-release characteristics.The percentageof drug released in iviro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第1期54-58,共5页
Acta Pharmaceutica Sinica
关键词
乙吗噻嗪
缓释片
药代动力学
抗心律失常药
Ethmozine
Sustained release tablet
γ-Scintiphoto technique
Pharmacokinetics
