摘要
目的 探讨膀胱癌组织中的MMP - 2与nm2 3-H1蛋白的表达及其临床意义。方法 采用免疫组化S -P法分析 6 3例手术切除膀胱癌中MMP - 2与nm2 3-H1蛋白的表达情况。结果 MMP - 2在膀胱移行细胞癌与乳头状瘤中的表达有显著性差异 (P <0 0 5 ) ,其表达与肿瘤分级与临床分期呈正相关 ;nm2 3-H1蛋白表达与肿瘤分期呈负相关 ,在肿瘤组织中随TCCB临床病理分期升高 ,MMP - 2表达增高趋势有显著性差异 ,而nm2 3-H1的表达随TCCB分级及临床分期的升高而呈现降低趋势 ,且有显著性差异 (P <0 0 5 )。结论 检测膀胱癌转移相关基因表达并分析其表达的相互关系 。
Objective To investigate the clinical significance of the expressions of nm23-H 1 and MMP-2 in bladder carcinoma.Methods Immunohistochemical study for nm23-H 1 and MMP-2 were performed on 63 cases of paraffin-embedded specimens of surgical carcinoma.Results There were significant difference in MMP-2 between the transitional cell carcinoma of bladder and mastoid tumor.The positive expression of MMP-2 was significantly increased with stage and grade (P<0.05).But the posstive expression of nm23-H 1 decreased with the stage and grade (P<0.05).Conclusion The expression of some metastasis-related genes can be used to estimte the metastatic potenciality and help for the adguvant treatment.
出处
《现代肿瘤医学》
CAS
2004年第2期95-96,共2页
Journal of Modern Oncology
基金
河北省科技厅科研基金资助项目 ( 0 3 2 2 6)
