摘要
目的 观察NP方案治疗ⅢB/Ⅳ期非小细胞肺癌的临床疗效和毒副反应 ,评价其临床应用的可靠性及安全性。方法 采用NP方案治疗晚期非小细胞肺癌 (NSCLC) 34例 ,男 2 5例 ,女 9例。病理类型为腺癌 19例 ,鳞癌 15例 ,ⅢB期 11例 ,Ⅳ期 2 3例 ;初治 2 6例 ,复治 8例。结果 部分缓解 (PR) 15例 ,稳定 (SD) 7例 ,进展 (PD) 12例 ,总有效率 (RR) 4 5 0 %。毒性反应主要为骨髓抑制 ,白细胞下降发生率 85 0 % ,Ⅲ度、Ⅳ度为 2 6 0 % ,静脉炎发生率为 5 3 0 %。结论 NP方案治疗ⅢB/Ⅳ期NSCLC疗效可靠 ,毒性反应能够耐受 ,安全性较好 ,价格相对便宜 。
Objective To evaluate the result of NP regimen in the treatment of non-small-cell lung cancer(NSCLC).Methods Twenty seven pationts with advanced NSCLC were enrolled in this study,25 males,9 females,adenocarcinoma was the most common type of malignancy,11 patients had stage ⅢB diease and 23 had stage Ⅳ,26 patients had no prior chemotherapy and 8 patients received previous chemotherapy.Results Partial response was observed in 15 patients with an overall rate of 45%.The main toxicity was neutropenia which was seen in all treated cases(26% in grades Ⅲ and Ⅳ),the local venous toxicity was observed in 53.0% of the patients.Conclusion A high response rate is obstained in advanced treated by NP regimen.the toxicity is mild,tolerable and effective.
出处
《现代肿瘤医学》
CAS
2004年第2期131-132,共2页
Journal of Modern Oncology
