摘要
目的：观察以去甲长春花碱为主的联合化疗治疗晚期非小细胞肺癌的疗效和安全性。方法：用去甲长春花碱（ＮＶＢ） 、丝裂霉素（ＭＭＣ）、顺氯氨铂（ＤＤＰ） 组成的ＭＮＰ方案治疗晚期非小细胞肺癌３７ 例。结果：３７ 例可评价疗效和毒性。总有效率为４８６％ 。结论：去甲长春花碱联合化疗治疗非小细胞肺癌有效，是目前治疗非小细胞肺癌最有效的方案之一。
Purpose: To evaluate the efficacy and safety profile of mitomycin ,vinerelbine and cisplatin combination in treating advanced non-small cell lung cancers (NSCLC) Methods: From October 1995 to June 1998, 37 patients received mitomycin ,vinorelbine and cisplatin (MNP regimen) combination chemotherapy Results: 37 patients were evaluated The overall response rate was 48 6%with 3 complete responses (CRs) and 15 partial responses (PRs) The median time to progression was 9 months and the median overall survival 9 6 months Grade Ⅲ～Ⅳleukopenia was occurred in 35 1%of patients and 10 8%of cycles Grade Ⅲ～Ⅳthrombopenia and anemia occurred in both of 10 8%of patients, 7 3%and 4 5%of cycles Other relative frequent side effects were alopecia (35 1%), Grade III nausea and vomiting (10 8%) Neurotoxicity was uncommon Conclusion: This study shows that mitomycin , vinorelbine and cisplatin combination chemotherapy is active and tolerable in advanced NSCLC It should be warrant for further study
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第9期681-684,共4页
Chinese Journal of Clinical Oncology
