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模拟微重力条件下大鼠肝细胞三维培养支架材料的筛选(简报)

SELECTION OF SCAFFOLDS OF RAT HEPATOCYTES IN THREE-DIMESION CULTURE UNDER SIMULATED MICROGRAVITY
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摘要 组织工程是一门新兴的边缘学科,它是利用体外培养的人体功能细胞与适当的细胞外基质或支架材料相结合,然后将其移植到体内病损部位以期达到修复目的. In order to investigate the biocompatibility, degradation and inflammatory reactions of poly benzyl glutamate (PBLG), poly lactie-co-glycolic acid (PLGA) and fibrin gel used as the scaffolds co -cultured with the hepatocytes of rats under simulated microgravity conditions in rotating wall vessel bioreactor (RWVB). PLGA is low biocompatibility, PBLG is medium biocompatibilty with rat hepatocytes. Fibrin gel is high biocompatibility, no toxic degradation and no inflammatory reactions. Fibrin gel can be used as three dimensional scaffolds of rat hepatocytes under simulated microgravity.
作者 张守全 高淑静 江青艳 劳全林 冯定远
机构地区 华南农业大学动物科学学院
出处 《实验生物学报》 SCIE CAS CSCD 北大核心 2004年第1期67-71,共5页 Acta Biologiae Experimentalis Sinica
基金 国家863-2项目资助(863-2.7.2.17)
关键词 模拟微重力 三维培养 肝细胞 大鼠 支架材料 细胞亲合性 Simulated microgravity. Three-dimension culture. Hepatocyte. Rat. Scaffold
分类号 Q25 [生物学—细胞生物学]
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参考文献22

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二级参考文献48

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2004年 第1期

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