摘要
自健康人肠道分离出一株肠球菌菌株DM 891129,经体外及动物实验证明具有降低血清胆固醇水平的作用。本制剂在动物实验证明安全可靠,在少数志愿者口服后,未见任何不良反应;对正常血清胆固醇水平无影响,对高胆固醇血症者血胆固醇水平有降低作用,作用强度呈用药依赖性及剂量依赖性。该制剂对甘油三酯水平作用不明显,其作用机制尚需进一步探讨。
One strain of enterococcus isolated from health child has proved to decrease the serum cholesterol level in vitro and in gerible rats.It is safety to take proved by acute toxic test in animal modle.This study is aimed to investigate the effect of the preparation of enterococcus on hypercholesterolemic volunteers after administrated it 1.5g、2.25g per day with one month of stoping for a peroid of 3 months and continually for one month respectively.The results show that there is no side-effect was observed during the administration of the preparation.It has great hypocholesterollemic effection in high cholesterol volunteers and no effect on those of normal serum cholesterol level,and the efficancy is dependent on the use of the preparation and the ues of dosage.This hypochoesterolemic mechanisms of the preparation is still under study.
出处
《中国微生态学杂志》
CAS
CSCD
1992年第3期16-19,共4页
Chinese Journal of Microecology
