摘要
目的 :观察不同药物对长春新碱 (VCR)血管外渗的治疗作用。方法 :用 2 1只新西兰大白兔 ,按 15mg/L药物浓度VCR将每只兔制作 4个部位血管外渗模型。局部分别用云南白药加 5 0 (v/v)乙醇膏湿敷、海普林软膏涂擦、5 0g/L硫酸镁湿敷 3种方法处理与不用药物组进行比较 ,于 3d、5d、7d行肉眼观察及组织病理学检查。结果 :3d无差异。 5d、7d云南白药乙醇、海普林与对照组比较有显著性差异 (P <0 .0 5 ) ;云南白药乙醇与海普林比较无差异 (P>0 .0 5 ) ,但充血、水肿、炎细胞浸润消退 ,海普林组次之 ;硫酸镁与对照组比较无差异 (P >0 .0 5 )。结论 :云南白药乙醇、海普林外敷对VCR血管外渗有良好防护作用。 5 0 %硫酸镁外敷仅能减轻水肿 ,无防护作用。
Objective: To observe the effects of different medicines on VCR vascular exosmose. Methods: 21 New Zealand rabbits were selected to made into models of VCR vascular exosomose in 4 parts with 15mg% drug concentration. The affected areas were locally compressed with Yunnan Baiyao mixed with alcohol, smeared with Hepudiod cream and compressed with 50%sulphate magnesium respectively, the effects of which were compared with the control group. The tissue pathological and the naked-eyed observations were carried on the 3rd, 5th and 7th day. Results: There was no difference among the 3 groups on the 3rd day. On the 5th and 7th day; there was obvious difference between the groups with Yunnan Baiyao mixed with alcohol and with Hepudiod cream, and the control group(P<0.05); there was no difference between the group with Yunnan Baiyao mixed with alcohol and that Hepudiod cream(P>0.05), but the group with Hepudiod cream was worse in congestion, swelling and infiltration of inflammatory cells regressed; there was no difference between the group with sulphate magnesium and the comparative group(P>0.05). Conclusion: Yunnan Baiyao mixed with 50% alcohol and Hepudiod have the excellent protective effects of VCR vascular exosmose, 50% solphate magnesium can only reduce the congestion when externally used, and has no protective effect.
基金
河南大学自然科学基础研究资助课题 (XK 0 10 16 )
