摘要
目的:探讨老年人多种性激素活性变化相互调控作用与认知功能障碍的关系。方法:用简易智力状态检查(MMSE)对216例60岁以上入选样本进行认知功能检查。按MMSE评分将样本分为2组,即认知功能正常组和认知功能障碍组;采用放射免疫学方法,测定入选样本血清泌乳素、雌二醇、睾酮、孕酮、卵泡刺激素和黄体生成素等性激素水平,比较同性别中认知功能正常组和认知功能障碍组性激素水平变化。结果:同性别中认知功能障碍组中的泌乳素、雌二醇和睾酮水平较认知功能正常组低(P<0.05)。结论:认知功能下降可能与雌二醇、睾酮和泌乳素水平降低有关。认知功能与多种性激素的活性变化及其之间的相互调控抗衡存在着密切关系,并非单一因素所能概括。
Objective: To explore the relationship between the effect of mutual regulation on the changes of bioactivities of several sex hormones and cognitive impairment in elderly people. Methods: The cognitive function of 216 recruited residents aged ≥ 60 were tested with Mini-Mental State Examination(MMSE). On the basis of MMSE scores, the samples were divided into two groups, the normal cognitive group and the impaired cognitive group; the following serum sex hormone levels of the recruited samples were measured with radioimmunoassay: they were pro-lactin, estradiol, testosterone, progesterone, follicle stimulating hormone and luteinizing hormone, and the changes of the sex hormone levels in the normal cognitive group compared with those in the impaired cognitive group in the same sex. Results: In the same sex, the levels of serum pro-lactin, estradiol and testosterone in the impaired cognitive group were significantly lower than those in the normal cognitive group (P <0.05). Conclusions: The degeneration of cognitive function may be associated with the decline of serum estradiol, testosterone and prolactin levels. Cognitive function is closely associated with the changes of bioactivities of several sex hormones and their mutual regulations or antagonism; therefore, it cannot be summarized with a single factor.
出处
《国外医学（脑血管疾病分册）》
2004年第4期264-266,共3页
Foreign Medical Sciences Cerebrovascular Diseases
