摘要
目的 研究马钱子生物碱在大鼠体内的组织分布。方法 大鼠静脉注射马钱子总碱后 ,定时用高效液相色谱法测定各组织中士的宁 (strychnine ,S)、马钱子碱 (brucine,B)、士的宁氮氧化物 (strychnineN oxide ,SNO)和马钱子碱氮氧化物(brucineN oxide ,BNO)的含量。结果 S、B、SNO和BNO在脑和脊髓中均有较多的分布。结论 S、B、SNO和BNO均可穿透血脑屏障 ,到达脑和脊髓 。
AIM To study the tissue distribution of strychnos nux vomica alkaloids in rats. METHODS Rats were given strychnos nux vomica alkaloids intravenously and strychnine(S), brucine(B), strychnine N oxide(SNO), brucine N oxide(BNO) in every tissue was determined by HPLC timely. RESULTS The concentration of S, B, SNO and BNO were high in brain and spinal marrow. CONCLUSION S, B, SNO and BNO all have the ability to permeate blood brain barrier.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2004年第4期421-424,共4页
Chinese Pharmacological Bulletin
关键词
马钱子
生物碱
组织分布
strychnos nux vomica
alkaloid
tissue distribution
