摘要
研究以卵磷脂类似物作载体的加氟衍生物对膀胱癌细胞T2 4 的抑制效果及对正常人胚二倍体细胞的毒性作用以及其浓度依赖性和时间依赖性 .动态活性结果表明 ,它对膀胱癌细胞T2 4 的抑制效果比原药稍大 .而膀胱癌细胞T2 4 对它的耐药性比替加氟要少 .
Ring-opening of cyclic glycerothiophospholipid-Tegefur conjugated by triethylamine produces the title compounds. This paper studies the compound anti-tumor activity against urianyl bladder cancer and toxicity activity against embargo cell of human being as well as its dependence on time and concentration. The result has shown that the title compound has better anti-tumor activity against human uriaryl bladder cancer cell and a slight higher toxicity against embrogo cell of human being than the Tegefur. The uriaryl bladder cancer cell has higher drug dependence on Tegefur.
出处
《湖南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2004年第2期10-12,共3页
Journal of Hunan University:Natural Sciences
基金
国家自然科学基金 ( 2 0 3 72 0 2 0 )
关键词
核苷
卵磷脂类似物
抗肿瘤活性
nucleotide
phosphocholine analogs
anti-tumor activity
