摘要
以碘活化的六乙基亚磷酰三胺为磷酰化及环化试剂，经一锅法合成并分离得到硫代环磷酸酯的两个非对映异构体，并对这两个非对映异构体的性质进行了研究．
New structural liponucleoside prodrugs were prepared in which 5 benzoyladenosine was covalently attached to five and six membered cyclic phospholipids. In the strategy for the synthesis, hexaethyl phosphorous triamide, activated by a catalytic amount of iodine, was used as the phosphorylating reagent in a one pot reaction resulting in a number of phospholipid adenosine conjugates.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第6期913-916,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
环甘油磷脂
缀合物
腺苷环甘油磷脂
抗肿癌药
Benzoyladenosine, Cyclic glycerophospholipid, Conjugates, Hexaethylphosphorous triamide, Diastereoisomers
