摘要
目的 :评价肝癌术后门静脉持续灌注化疗对预防肝癌术后复发的临床疗效。方法 :将1999年1月至2001年12月共77例行肝癌根治性切除后留置皮下埋藏的门静脉药物泵灌注化疗的患者随机分为一次性推注给药组(Ⅰ组 )、4h滴注给药组 (Ⅱ组 )和24h持续滴注给药组 (Ⅲ组 )。全部病例均在手术后3周开始分别以不同的注药方式经门静脉灌注化疗 ,每1至3个月重复。结果 :随访24个月 ,24h持续滴注给药组术后1～2年的复发率分别为8.0 %和24.0%。与一次性推注给药组及4h滴注给药组相比均有显著性差异 (P<0.05)。结论 :肝癌术后经门静脉24h持续灌注化疗可以进一步降低肝癌根治性切除术后的复发率 。
Objective:To study the clinical value of prevention from recurrence after radical resection of liver cancer by consistent portal vein chemotherapy(PVC).Methods:From Jan.1999to Dec.2001,Implantable drug deliver system(IDDS)was planted in77cases of liver cancer after they had been undergone radical resection.All of them were randomly divided into three groups with different way of injection via IDDS.27cases of quickly injection were given in group I.25cases of injection within4hours were given in groupⅡ.25cases of injection within24hours were given in groupⅢ.All of them began PVC in three weeks after resection.Results:All patients were followed up over24months.The recurrence rate of the patients with PVC within24hours(groupⅢ)for one and two for one and two years were8.0%and24.0%reˉspectively.There were siginificent differences between groupⅢand groupⅠor groupⅡ(P<0.05).Conclusion:Consistent portal vein chemotheray within24hours after radical resection of liver cancer may further decrease postoperative recurrence rate.
出处
《天津医科大学学报》
2004年第1期30-32,共3页
Journal of Tianjin Medical University
基金
天津医科大学肿瘤医院院级课题(编号 :0050)
关键词
肝癌
根治性切除
门静脉化疗
复发
Hepatocellar carcinoma
Radical resection
Portal vein chemotherapy
Recurˉrence
