摘要
目的 :用比色法测定水杨酸钠的光密度值 ,并计算血浆半衰期。方法 :给 1 1只家兔静脉注射 1 0 %的水杨酸钠溶液 2毫升 /公斤 ,用 72 1 -I型分光光度计测定给药瞬间和隔 30分钟时的血浆光密度值 ,计算水杨酸钠的血浆半衰期。结果 :t1/2 =2 8.96± 4 .97。结论 :绝大多数药物是按一级动力学规律消除 ,因此每一种药物都有固定的血浆半衰期 。
Objective:To determine the numerical value of light dense of sodium salicylate by colorimetric analysis,and calculate its plasma half life.Methods:After intravenous injection 10 percent sodium salicylate solution 2 ml/kg into eleven rabbits,determined plasma numerical value of light dense once instantly and the second time determined it 30 minutes later by 721-type spectroscope,calculated plasma half life of sodium salicylate.Results:t\-\{1/2\}=28.96±4.97.Conclusion:Most drugs are eliminated in the rule of first order elimination kinetics,therefore plasma half life of each drug is constant and it doesn't vary with plasma concentration.
出处
《大同医学专科学校学报》
2004年第2期1-2,共2页
Journal of Datong Medical College
