摘要
目的:观察麻醉和手术对家兔血浆水杨酸钠半衰期的影响。方法:将动物分为:非手术组(对照组)和手术组(全身麻醉组与局部麻醉组)。经耳缘静脉注射10%的水杨酸钠溶液(1.5 ml.kg-1)10 min和40 min后,分别采取各组的动脉血液和静脉血液,用721-I分光光度仪测量血浆水杨酸光密度值,计算其半衰期。结果:手术组的半衰期比对照组的明显延长(P<0.05,t=3.56);全身麻醉组的半衰期比局部麻醉组的明显延长(P<0.05,t=2.3);全身麻醉组或局部麻醉组动、静脉血液的半衰期相比无差异。结论:麻醉和手术能延长家兔血浆水杨酸钠的半衰期,而动、静脉血液间无差异。
To observe the effect of rabbit plasma half-life of salicylic sodium under anesthesia and surgery. Methods： Animals were divided into four groups： control group, operation group, generation anesthesia group and local anesthesia group. Rabbits were injected 10% sodium salicylic solution 1.5 ml kg^-1 by the edge of ears＇ vein, 10 and 40 min later, collected respectively every group＇s artery and vein blood that measured the half-life of plasma salicylic sodium by 721-I Atomic Absorption spectrophotometer. Results： There were significant differences operation group and non-surgical group （P〈0. 05, t=3.56）, the same as generation anesthesia group and local anesthesia group （P〈0. 05, t= 2. 3）, there were no difference between artery blood and vein blood in generation anesthesia group, so did local anesthesia group. Conclusion： surgery and anesthesia could extend the rabbit plasma half-life of salicylic sodium. But the changes of rabbit plasma half-life of salicylic sodium was no difference between artery and vein blood in anesthesia groups.
出处
《四川生理科学杂志》
2009年第1期19-21,共3页
Sichuan Journal of Physiological Sciences
基金
川北医学院机能实验中心学生设计性课题
关键词
水杨酸钠
半衰期
手术
麻醉
Salicylic sodium
Half-life
Operation
Anesthesia
