摘要
本文对有自然流产史的妇女及其配偶进行了 HLA—Ⅰ类抗原测定。其中流产仅1～2次者47对,流产3次或以上(习惯性流产)者42对.并以40对正常生育的夫妇作比较.结果显示有流产史的夫妇间存在 HLA 相容性增加的趋向。流产组夫妇间共有2个或以上抗原者显著高于正常对照组。而夫妇间无一抗原相同者,则习流组显著低于对照组。与国外的许多报导一致。提示夫妇间的人类主要组织相容性抗原相容性增加,即双方共有2个或以上的 HLA 抗原,产生 HLA 抗原纯合子胎儿的机会增加,以致妊娠得不到足够的免疫防护,可能是导致自然流产的一个因素。
89 couples with spontaneous abortions were tested for HLA—ABC typing.In this group,47couples had one or twe miscarriages and 42 couples had three or more recurrent abortions.Com-paring with 40 normal fertile couples,the couples With spontaneous abortions had higher HLA chass Ⅰ antigens sharing.The observed frequency of two or more antigens sharing in abortiongroup is 31.46%,significantly higher than 7.5% in the fertile couples.The frequency of none
antigen sharing in abortion couples is 22.47%,in control group is 42.5%,a significant differ-ence.Our data is in agreement with many studise to date.It suggests that an increase of MH-Cantigens sharing in couples,i.e.sharing two or more antigens,may be at higher risk to conceive a HLA homozygote embryo.It may be a factor be at higher risk to conceive a HLA homozygote embryo.It may be a factor of spontaneous abortion because of lacking the immunological protec-tion during pregnancy.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1992年第4期233-235,共3页
Chinese Journal of Immunology
基金
国家中医药管理局资助
