摘要
目的:评价阿维A治疗严重类型银屑病的临床疗效。方法:23例银屑病患者,应用阿维A治疗,成人阿维A初始剂量为0.75～1.00mg/(kg·d),平均维持剂量为10～30mg/d,平均疗程4～6周;儿童阿维A初始剂量为1.00mg/(kg·d),起效后维持量为0.10～0.20mg/(kg·d),最大不超过35.00mg/d。结果:在严重的寻常型斑块状银屑病、红皮病型银屑病、泛发性脓疱型银屑病中的有效率分别为87.5%、83.3%、100.0%。而关节病型银屑病有效率仅为50.0%。对皮肤干燥、口干、瘙痒、唇炎、掌跖脱屑以及血脂增高等不良反应进行了对症处理,结果均好转或消失。结论:阿维A治疗严重类型的银屑病疗效显著。
Objective:To assessment the therapeutic effects and adverse reactions of acitretin on severe psoriasis.Methods:Twenty three inpatients with severe psoriasis(18males,5females)were treated with acitretin.In adults.initial dose of ac-itretin was0.75-1.00mg /(kg·d),average30-70mg /d,average course4-6weeks,decreased gradually to maintenance dose(average10-30mg /d),after an effective dose was reached.In children,initial dose was1.00mg /(kg·d),maintenance control with0.10-0.20mg /(kg·d),total less than35mg /d.Results:The results showed that the response rate was87.5%(severe plaque psoriasis),83.3%(erythroderma psoriaticum),100.0%(generalized pustular psoriasis),respectively,only50.0%of the psoriasis arthropathica patients with improvement.Adverse drug reactions of acitretin such as dryness of skin and mouth,pru-ritus,cheilitis,desquamation of palm and sole,and hypertriglyceridemia were improved or obliterated with expectant treatment.Con clu sions:Acitretin is effective in the severe types of psoriasis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2003年第10期610-611,共2页
Journal of Clinical Dermatology
关键词
银屑病
阿维A
治疗
psoriasis
acitretin
treatment
