摘要
将132名甲型肝炎易感儿童随机分为3个组。每组44人。第1组儿童接种H_2M_(20)K_16疫苗,第2组接种H_2M_(20)K_7疫苗。全程接种1针,皮下注射,剂量为10^(6·5)TCID_(50)/1ml。第3组为对照组不接种疫苗。两组疫苗接种均安全。免后1～2个月的抗-HAV阳转率均达80％以上。在观察地区发生甲型肝炎流行时,两组疫苗的保护率分别为100.00％和80.02％。说明在甲型肝炎流行季节前接种H_2M_(20)K_(16)或H_2M_(20)K_7疫苗均可达到有效控制甲型肝炎的流行。
This paper reports on 132 children Susceptible to hepatitis A which randomly divided into three groups, There were 44 children in each group.Group one was inoculated with H_2Me_(26)K_(16) vaccine while group two with H_2M_(20)K_7 vaccine. In both inoculative groups children were subcutaneously given one dosage 10^(6.5)TCLD50/1ml of the vaccine. Group three did not get any inoculation and served as controls. Both groups had safe inoculation. Anti-HAV seroconversion rate reached more than 80.00% 1～2 months after inoculation.The protective rates against HAV among two vaccinated groups were 100.00% and 80.02% respectively during an hepatitis A epidemic in the observational area. The study demonstrated that when H_2M_(20)K_(16)or H_2M_(20)K_7 vaccine being used to children prior to the epiemic season of hepatitis A, the epidemic of hepatitis A might effectilvely be under controlled
关键词
免疫应答
接种反应
HAV减毒疫苗
Attenuated live HAV vaccine Immune response Inoculated reaction
