摘要
本文对虫媒病毒作为我国病毒性脑炎病原的作用进行了血清流行病学研究。1988～1990年在我国15个地区搜集了614例疑似病毒性脑炎病例的急性期和恢复期血清;对3种主要虫媒病毒群(黄病毒群、甲群、加里福尼亚(CAL)血清群病毒)抗原的血凝抑制(HI)抗体进行了测定,结果大部分地区的病例双份血清对黄病毒群和甲群虫媒病毒 HI 的滴度呈4倍升高。未发现对 CAL 病毒群中的 SSH 病毒HI 滴度呈4倍升高的病例。甲群虫媒病毒感染病例的年龄为50天～32岁。黄病毒感染的病例年龄为6个月～50岁。严重的中枢神经系统症状在黄病毒感染病例中较多。本研究肯定了黄病毒作为我国病毒性脑炎病原的重要性。并提供了在我国可能存在1种或1种以上可引起神经症状的甲群虫媒病毒感染的证据,并阐述了甲群虫媒病毒症状性感染在我国地理分布的概貌。
The seroepidemiolgical study was underta- ken to determine the role of arboviruses as eti- ological agents of encephalitis.Paired sera were collected during mosquito seasons in 1988 ～1990 from 614 patients with suspected viral encephalitis in 15 regions and tested for HI ant- ibodies to arboviruses of three major serogr- oups (alphaviruses (ALP),flaviviruses (FLA), California (CAL) serogroup).Seroconversions were documented to ALP virus antigens in 13.0% and 18.7% of patients respectively in most of the study areas.No CAL gruop seroco- nversions were detected.The age of ALP virus seroconvertors ranged from 2 months to 32 years and of FLA virus seoconvertors from 6 months to 50 years.Serious central nervous system manifestations were seen more commonly in FLA virus seroconvertors.This study affirms the importance of FLA viruses as causative age- nts of encephalitis in PRC and provides evidence that one or more ALP viruses are causing sym- tomatic infections with neurological involvement in PRC and the geographic distribution of infe- ctions with ALP virus roughly.
关键词
虫媒病毒
脑炎
病原
血清流行病学
Arboviruses Etiological Agents of Encephalitis Seroepidemiology
