摘要
目的 观察免疫增强型肠内营养制剂茚沛对肺癌化疗患者营养和免疫功能的影响。方法 2 5例肺癌化疗患者 ,随机分为两组 :1、免疫营养组 (茚沛 诺华公司 ,n =13) ;2、标准营养组 (能全力 纽迪希亚公司 ,n =12 )。两组使用等热量肠内营养 :30kcal/ (kg .d) ,分别于化疗前、化疗后第 3、8天抽取静脉血 ,检测营养指标 (血清清蛋白、前清蛋白、转铁蛋白 )与免疫指标 (IgA、IgM、IgG)。结果 两组患者化疗前后均有免疫功能的降低 ,但化疗后第 8天 ,免疫营养组比标准营养组的血清IgG水平有显著增加 (12 .39± 1.89g/L vs 10 .92± 1.4 5g/L ,P <0 .0 5 ) ,血清前白蛋白浓度有显著增加 (0 .2 2± 0 .0 7g/Lvs0 .16± 0 .6 4 g/L ,P <0 .0 5 )。结论 肺癌化疗患者且有营养不良者使用肠内免疫增强型营养 ,可以改善肺癌患者化疗后免疫功能的低下 ,增加蛋白的合成。护理上应注意合理调整营养液的浓度、速度、温度。
Objective To evaluate the effect of enteral immuno nutrient on nutrition and host immune in patients with lung cancer during chemotherapeutic courses.Methods Twenty-five patients with lung cancer were randomly classified into immunonutrition group to receiving an enriched enteral diet, Impact (n=13),and standard enteral diet group receiving,Nutrison(n=12). The daily nutritional goal was 30 kcal/kg.Serum immunological and nutritional variables in both groups were assessed in perichemotherapy on the third and eighth day after initiation of chemotherapy.Results The Immune function in lung cancer patients was decreased in both groups, however,on the eighth day after chemotherapy, the serum levels of IgG and prealbumin in the immunonutrition group were significantly higher than in the control group,with IgG:12.39±1.89 vs 10.92±1.45 (g/L) (P<0.05);prealbumin:0.22±0.07 vs 0.16±0.64 (g/L) (P<0.05),respectively.Conclusion Administering enriched enteral diet in lung cancer patients with malnutrition can improve the host immune function and increase the syntheses of serum protein.
出处
《解放军护理杂志》
2004年第3期14-16,共3页
Nursing Journal of Chinese People's Liberation Army
