摘要
目的 :探讨细胞生长调节因子TGFβ1在子宫颈鳞状细胞癌中的表达及其意义。方法 :采用免疫组织化学SP方法 ,检测 31例子宫颈鳞癌组织中TGFβ1的表达。结果 :TGFβ1在宫颈鳞癌细胞浆及细胞外基质中均可见表达。分化越差 ,临床分期越晚 ,癌细胞中的阳性表达率越低 ,细胞外基质中的阳性表达率越高。宫颈鳞癌细胞中 ,低分化组TGFβ1表达阳性率与高分化及中分化组相比 ,差异具有显著性 (P <0 .0 5 ) ,高与中分化组间差异无显著性 (P >0 .0 5 )。在宫颈鳞癌细胞外基质中 ,高分化组TGFβ1表达阳性率与低分化及中分化组相比差异具有显著性 (P <0 .0 5 ) ,中与低分化组差异无显著性 (P >0 .0 5 )。胞浆和细胞外基质中的阳性率在临床分期Ⅰ和Ⅱ期 ,Ⅰ期和Ⅲ期间差异均具有显著性 (P <0 .0 5 ) ,Ⅱ期和Ⅲ期间差异不具有显著性 (P >0 .0 5 )。结论 :TGFβ1的表达下调与宫颈鳞癌细胞分化程度、临床分期有关 。
Objective To explore the significance and expression of transforming growth factor-β1 (TGFβ 1) in cervical squamous carcinoma. Methods The expression of TGFβ 1 in 31 cases of cervical squamous carcinomas were detected by SP immunohistochemical staining. Results TGFβ 1 expression was found in both cytoplasm and extracellular stroma. TGFβ 1 expression increased when the pathologic grade was getting worse and clinical stage was of later the in extracellular matrix and decreased in cytoplasm. The positive rate of TGFβ 1 in cytoplasm in the low grade group was lower than that in the high and middle grade (P<0.05). The positive rate of TGFβ 1 in extracellular stroma in the high grade group was significantly lower than that of the other two groups. In cytoplasma,the TGFβ 1 expression was obviously higher in stageⅠthan in stage Ⅱ and Ⅲ, while it was lower in extracellular stroma (P<0.05). There was no significant difference between stage Ⅱand Ⅲ (P>0.05).Conclusion The decrease of TGFβ 1 expression may play an important role in the differentiation and devepolment of cervical squamous carcinoma. High expressions of TGFβ 1 in extracellular stroma may be related to the matastasis of cervical squamous carcinoma.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第1期44-46,共3页
Journal of Central South University ：Medical Science
