摘要
目的 建立噻奈普汀钠片溶出度测定方法。方法 以水为溶出介质 ,转篮法 ,转速 10 0r/min ,4 5min为取样点 ,检测波长为 2 2 5nm。结果 噻奈普汀钠在 2 .74～ 2 7.4 4 μg·ml-1范围内 ,浓度与吸收度呈良好线性关系 (r =0 .9998)。回收率为 10 0 .1% ,RSD 为 0 .6 1% ,三批溶出度平均值均大于 90 %。结论 本法快速简便 。
Aim This paper reported the method to study of Tianeptine Sodium tablet's dissolution test.Method Water was used as dissolution medium,basket method,100r/min,detection wavelength was 225nm,time was 45 minutes.Results A linearity range of 2.74～27.44μg·ml -1 was obtained,The recoveries was 100.1%,RSD was 0.61%.Conclusion This method was simple,rapid and good reproducible.
出处
《解放军药学学报》
CAS
2004年第1期32-33,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
