摘要
针刺镇痛的研究中,外周神经中哪一类纤维参与针刺镇痛效应一直是个争论的问题。候宗濂等认为C纤维传入是主要的,张香桐等提出外周神经中Ⅱ、Ⅲ类纤维是重要的。
Experiments were carried out in rats anaesthetized with urethane (1g/kg). Late discharges of spinal dorsal horn neurons were recorded as noxious responses to strong stimulation of right tibial nerve (a train of 3 pulses, 25V, 1ms). Left St.36 and Sp.6 were stimulated electrically (100Hz, 3V or 6V, 1ms). Left sciatic nerve was exposed and soaked for 15 min in 1.5% capsaicin or vehicle 24 hours before experiment. Left femoral nerve was sectioned. Spinal cord was transected at T4 level in spinal rat. Intact rats. 1) EA group (N=12). Sciatic nerve was not treated. Late dischages of neuron were reduced to 44.6±18.3% of control (P<0.02) by EA(3v). 2) Capsaicin group (N=15). Late discharges were reduced to 89.8±6.0% of control (P>0.05) by EA(3V). 3) Vehicle group (N=10). Late discharges were reduced to 51.2±15.6% of control (P<0.05) by EA(3V). 4) There was a statistical difference (P<0.05) between capsicin and vehicle group. Spinal rats: 1) EA group. Late discharges of neuron were reduced to 67.6±10.3% of control (P<0.02) in 11 neurons by EA(3V), 72.7+8.8% (P<0.01) in 9 neurons by EA(6V). 2) Capsaicin group. Late discharges were 110±21.0% of control (P>0,05) in 13 neurons after termination of EA (3V), 90.7±12.9% (P>0.05) in 10 neurons after EA (6V). 3) Vehicle group. Late discharges were reduced to 67.7±8.1% of control (P<0.02) in 12 neurons by EA (3V), 68.1±5.0% (P<0.01) in 10 neurons by EA (6V). 4) There was a statistical difference (P<0.05) between capsaicin and vehicle group for 3V, no statistical difference (P>0.05) for 6V. C fiber of periphral nerve is main component involved in effect of EA analgesia in intact rats. Both A and C fiber of periphral nerve involved in effect of EA analgesia in spinal rats.
出处
《针刺研究》
CAS
CSCD
1992年第1期48-53,共6页
Acupuncture Research
