摘要
本文用放免法测定151例神经疾患病人和21例正常人CSF中β_2-微球蛋白含量。病变组包括急性脑血管病、颅内感染性疾病、脊髓疾病、症状性癫病和其他疾病。正常组均值为1.21μg/ml。病变组均值普遍增高,除急性脊髓炎之外与正常组对比均有显著性差异,但以出血性脑血管病、细菌或真菌性脑膜炎和脊髓压迫症者升高尤为显著。资料表明CSF中β_2-微球蛋白不适于做为特异性诊断指标,但对于同一组疾病中的各个病种之间的鉴别有一定的意义。
The level of CSF β2-microglobulin(β2-m) was determinated in 151 patients with nervous system disease including acute cerebrovascular diseases, intracranial infection, spinal cord diseases, symptomatic epilepsy and others. The mean level of CSF β2-m in control was 1. 21μg/ml. Except the patients with acute myelitis, β2-m level of CSF in the patients with other diseases is significantly higher than that of the control,especially in the patients with hemorrhagic cerebrovascular diseases , meningitis of bacteria or mycotic organnism and compressive myelopathy. The result showed that the elevation of CSF β2-m level is not a specific diagnotic indicator,yet it is of some value in the differential diagnosis between hemorrhagic and ischemic cerebrovascular disease, bacteria and aseptic intracranial infection,compressive and noncompressive myelopathy.
关键词
脑脊液
β2
微球蛋白
神经系统病
nervous system disease
cerebrospinal fluid
β_2-microglobulin
radioimmunoassay
