摘要
应用正交试验法研究非离子型聚丙烯酰胺和氯化铝六水合物的浓度、pH对西索米星发酵液过滤预处理过程的影响并确定适宜的絮凝工艺条件。结果表明:絮凝剂的浓度与pH对过滤过程的影响显著。最佳絮凝工艺条件为聚丙烯酰胺浓度0.125g/L、氯化铝六水合物浓度8 g/L,pH 5。经絮凝处理的发酵液过滤常数比未经絮凝处理的提高28倍。
The influences of concentration of non-ion polyacrylamide, aluminium chloride hexahydrate and pHon the pretreatment process before filtration of sisomicin fermentation broth were studied with orthogonal experiment toobtain the optimal conditions. The flocculating effect was the best at pH 5 when the concentrations of polyacrylamide andaluminium chloride hexahydrate were 0.125 and 8 g/L, respectively. The filtration coefficient was increased by 28 times.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第3期141-143,共3页
Chinese Journal of Pharmaceuticals
基金
福建省教育厅资助项目(JB00093)
福建省科技三项资助项目(K20018)
关键词
西索米星
发酵液
絮凝
聚丙烯酰胺
氯化铝六水合物
sisomicin
fermentation broth
flocculation
polyacrylamide
aluminium chloride hexahydrate
