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中枢神经系统辐射损伤的细胞与分子机制研究进展 被引量：2

Advances in study of cellular and molecular mechanisms of radiation-induced CNS injury
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摘要 了解中枢神经系统(centralnervoussystem,CNS)的辐射损伤机制,对增强CNS的辐射耐受程度和治疗辐射引起的CNS损伤具有重要意义。主要从神经元、少突胶质细胞、脱髓鞘及血管系统等方面概述CNS辐射损伤的细胞机制,并简要介绍辐射诱导CNS的细胞凋亡信号转导及基因表达等分子机制。 Understanding the mechanisms of radiation-induced CNS injury may help to develop strategies to increase the radiation tolerance and treat CNS injury induced by radiation.The article re-views the cellular mechanisms about neurons,oligodendrocytes,demyelination,vasculature and so on,and the molecular mechanisms of the apoptosis signal transduction and gene expression induced by radi-ation.
作者 张燕 陈肖华
机构地区 军事医学科学院放射医学研究所
出处 《国外医学（放射医学核医学分册）》 2004年第1期41-44,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 中枢神经系统辐射损伤 细胞机制 分子机制 少突胶质细胞 脱髓鞘 细胞凋亡 信号转导 基因表达 radiation injury central nervous system cellular and molecular mechanisms
分类号 R818 [医药卫生—放射医学]
  • 相关文献

参考文献12

  • 1Romero AA, Gross SR, Cheng KY, et al. An age-related increase in resistance to DNA damage-induced apoptotic cell death is associated with development of DNA repair mechanisms[J]. J Neurochem, 2003, 84(6): 1275-1287.
  • 2Pena LA, FuksZ, Kolesnick RN. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency[J]. Cancer Res, 2000, 60(2): 321-327.
  • 3Offer H, Erez N, Zurer I, et al. The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA[J]. Carcinogenesis, 2002, 23(6):1025-1032.
  • 4Chong MJ, Murray MR, Gosink EC, et al. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system[J]. Proc Natl Acad Sci USA, 2000, 97(2): 889-894.
  • 5Raju U, Gumin GJ, Tofilon PJ. Radiation-induced transcription factor activation in the rat cerebral cortex[J]. Int J Radiat Biol, 2000, 76(8): 1045-1053.
  • 6Gobbel GT, Chan PH. Neuronal death is an active, caspasedependent process after moderate but not severe DNA damage[J]. J Neurochem, 2001, 76(2): 520-531.
  • 7Chow BM, Li YQ, Wong CS. Radiation-induced apoptosis in the adult central nervous system is p53-dependent[J]. Cell Death Differ, 2000, 7(8): 712-720.
  • 8Cammer W. Effects of TNF alpha on immature and mature oligodendrocytes and their progenitors in vitro[J]. Brain Res,2000, 864(2): 213-219.
  • 9Amano T, Inamura T, Wu CM, et al. Effects of single low dose irradiation on subventricular zone cells in juvenile rat brain[J]. Neurol Res, 2002, 24(8): 809-816.
  • 10Baatout S, Derradji H, Petitfour O, et al. Mechanisms of radio-induced apoptosis [J]. Can J Physiol Pharrnacol, 2002,80(7): 629-637.

同被引文献14

  • 1刘强.放射性脑损伤研究现状[J].国外医学（放射医学核医学分册）,2004,28(4):178-181. 被引量：14
  • 2Cao MD,Chen ZD,Xing Y.Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reaction.Cell Biol Int,2004,28(3):223-228.
  • 3Hong JH,Chiang CS,Tsao CY,et al.Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular response?.Int J Radiat Oncol Biol Phys,2001,51(2):296-303.
  • 4Kim SH,Lim DJ,Chung YG,et al.Expression of TNF-α and TGF-β1 in the rat brain after a single high-does irradiation.J Korean Med Sci,2002,17(2):242-248.
  • 5Romero AA,Gross SR,Cheng KY,et al.An age-related increase in resistance to DNA damaged-induced apoptotic cell death is associated with development of DNA repair mechanisms.J Neurochem,2003,84(6):1275-1287.
  • 6Gobbel GT,Chan PH.Neuronal death is an active,caspasedependent process after moderate but not severe DNA damage.J Neurochem,2001,76(2):712-720.
  • 7Tofilon PJ,Fike JR.The radioresponse of the central nerous system:a dynamic process.Radiat Res,2000,153(3):357-370.
  • 8Kutita H,Kawahara N,Asai A,et al.Radiation-induced apoptosis of oligodendrocytes in the adult rat brain.Neurol Res,2001,23(8):869-874.
  • 9Cammer W.Effects of TNF alpha on immatuare and mature oligodendrocytes and their progenitors in vitro.Brain Res,2000,864(2):213-219.
  • 10Pena LA,Fuks Z,Kolesnick RN.Radiation-induced apoptosis of endothelial cells in the murine central nervous system:protection by fibroblast growth factor and sphingomyelinsae deficiency.Cancer Res,2000,60(2):321-327.

引证文献2

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国外医学（放射医学核医学分册）
2004年 第1期

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