摘要
神经干细胞(neural stem cells,NSCs)的增殖、分化与中枢神经系统(central nervous system,CNS)的自我更新、神经病理损伤的修复密切相关。细胞因子可以调节NSCs的增殖,诱导NSCs进行特定分化,这对于治疗CNS损伤疾病具有重要的临床意义。该文综述了生长因子(growth factor,GF)、白细胞介素(interleukin,IL)、干扰素(interferon,IFN)等常见细胞因子对NSCs增殖和分化的影响及其可能的作用机制。其中,神经生长因子(nerve growth factor,NGF)、碱性成纤维生长因子(base fi broblast growth factor,b FGF)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)促进NSCs增殖,IL-1β、IL-17、IFN-α抑制NSCs增殖。IL-1α、血管内皮生长因子(vascular endothelial growth factor,VEGF)、IFN-γ促进NSCs向神经细胞方向分化,TNF-α、IL-1β促进NSCs向神经胶质细胞分化。有些细胞因子仅对增殖或分化有影响,有些细胞因子对增殖和分化均有影响。此外,大多数细胞因子的不同亚型产生的效应大致相同,但少数亚型可能会产生不同甚至相反的效应。
The proliferation and differentiation of neural stem cells （NSCs） are closely related to selfrenewal and neuropathological lesion repair of the central nervous system （CNS）. Cytokines-induced amplification and differentiation of NSCs contribute to the treatment of CNS injury. We here review the impacts of growth factor （GF）, interleukin （IL）, interferon （IFN） and other cytokines on NSCs proliferation and differentiation and the underlying mechanism. Among them, nerve growth factor （NGF）, bFGF, tumor necrosis factor-α （TNF-α） promote NSCs proliferation while IL- 1β, IL- 17, IFN-a inhibit NSCs proliferation. IL- 1 α, vascular endothelial growth factor （VEGF）, IFN-γ promote neural differentiatiation of NSCs while TNF-α, IL-α IL-1β promote glial differentiation. Some cytokines affect either NSCs proliferation or NSCs differentiation, while some have effects on them both. In addition, the effects of different subtypes of most cytokines are roughly the same, but a few may have different and even opposite effects.
出处
《中国细胞生物学学报》
CAS
CSCD
2016年第7期886-896,共11页
Chinese Journal of Cell Biology
基金
中央高校基本科研业务费资助的课题~~
