摘要
采用阿维A酯与阿维A治疗13例儿童脓疱型银屑病,其中用阿维A酯治疗7例,用阿维A治疗5例,另有1例患儿首次用阿维A酯治疗,4年后改用阿维A治疗。起始剂量为0.3～1mg/(kg·d),病情控制后每2周减量1次,维持剂量为0.1～0.2mg/(kg·d),疗程为2个月。阿维A酯有效率为77.8%,阿维A为83.3%,用药后7～8d体温下降、无新发脓疱出现。最常见的不良反应有口干、唇干,全身皮肤干燥及瘙痒。治疗结果表明阿维A酯与阿维A治疗儿童脓疱型银屑病疗效相近,且停药无反跳现象,可在实验室定期监测下作为首选药物。
Thirteen cases of pustular psoriasis in children were treated with etretinate and acitretin,in which7cases were treated with etretinate,and5cases with acitretin,and1case was treated with etretinate first,four years later with acitretin.The initiating dosage(0.3～1mg /kg daily)could be abated per2weeks once while the patients condition was controlled,the maintenance dosage being0.1～0.2mg /kg daily,and the course of therapy was2months.The total response rate was77.8%in etretinate treatment,and83.3%in acitretin treatment.The time needed to descend fever and stop the new pustular forma-tion was7～8days.The most common side-effects were xerostomia,cheilosis,xerosis and itch.These results suggested that the efficacy of etretinate and acitretin to treat pustular psoriasis in children was similar,and there was no phenomenon of rebound during withdrawal.Therefore both of them could be first chosen for the treatment of pustular psoriasis under the monitoring of the laboratory tests.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2003年第6期354-355,共2页
Journal of Clinical Dermatology
